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KMID : 0858420090110010001
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Korean Journal of Stroke
2009 Volume.11 No. 1 p.1 ~ p.9
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Aspirin and Clopidogrel Resistance in Stroke Patients
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Bang Oh-Young
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Abstract
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Background: An increasing number of anti-platelet agents of various action mechanisms has been tested and used to prevent recurrent ischemic events in patients with ischemic stroke. However, the preventive effects of these anti-platelet agents were still limited. Recently, impaired responses to anti-platelet therapy assessed by laboratory tests have been reported to be associated with an increased risk of recurrent ischemic events after stroke or cardiovascular events.
Contents: In this review, 1) the mecha-nisms of anti-platelet failure and anti-platelet resistance, 2) laboratory methods to detect anti-platelet resistance, 3) prevalence and clinical implication of it, and 4) possible management for this situation will be discussed.
Conclusion: Although there have been increasing evidences of impact of anti-platelet resistance on the recurrent clinical events, at present there was no solid criteria for anti-platelet resistance or definite evidence to recommend a change anti-platelet medication according to the laboratory results in clinical practice. Hopefully, the further studies on anti-platelet resistance may guide the pharmacologic treatment for stroke prevention in patients with ischemic stroke.
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KEYWORD
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Stroke, Aspirin, Clopidogrel, Resistance
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